The multiple faces of marginal zone lymphomas
نویسندگان
چکیده
منابع مشابه
Non-MALT marginal zone lymphomas.
The concept of marginal zone B-cell lymphomas was developed in the 1990s for lymphomas whose cells originate from B lymphocytes normally present in a distinct anatomical location, the so-called ‘marginal zone’ (MZ). MZ has been described in the lymphoid organs—spleen and lymph nodes—and in nonlymphoid organs—mucosa-associated lymphoid tissue (MALT) or non-mucosal tissue such as skin, orbit and ...
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In an area of lymphoma classification still being defined, marginal-zone lymphomas have distinctive immunohistochemical and cytogenetic features that distinguish them from mantle-cell and follicular lymphomas. There are three subtypes: the extranodal mucosa-associated lymphoid tissue (MALT) lymphomas, the nodal monocytoid B-cell (MBCL) lymphomas, and the splenic marginal-zone lymphomas. The MAL...
متن کاملNodal marginal zone B-cell lymphomas may arise from different subsets of marginal zone B lymphocytes.
Nodal marginal zone B-cell lymphoma (MZL) is a rare and not extensively studied entity that accounts for approximately 2% of all non-Hodgkin lymphomas. Complementarity-determining regions 2 and 3 (CDR2, CDR3) of the immunoglobulin heavy-chain variable region (V(H)) genes were amplified by polymerase chain reaction (PCR), cloned, and sequenced in 8 patients with nodal MZL. All showed a potential...
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The dura is a rare site of involvement by marginal zone lymphoma (MZL) and the biology of dural MZL is not well understood. We performed genome-wide DNA copy number and targeted mutational analysis of 14 dural MZL to determine the genetic landscape of this entity. Monoallelic and biallelic inactivation of TNFAIP3 by mutation (n=5) or loss (n=1) was observed in 6/9 (67%) dural MZL exhibiting pla...
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12 Department of Haematology, Institut Jules Bordet (ULB), Brussels, Belgium Department of Haematology, Cliniques Universitaires St Luc, Brussels, Belgium Department of Haematology, Hôpital de Jolimont, Haine St Paul, Belgium Department of Haematology, Universitair Ziekenhuis, Gent, Belgium Department of Haematology, Universitair Ziekenhuis, Antwerp, Belgium Department of Haematology, Centre Ho...
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ژورنال
عنوان ژورنال: Hematological Oncology
سال: 2017
ISSN: 0278-0232
DOI: 10.1002/hon.2400